Treatment-induced tumor cell apoptosis following high-intensity interval training and saffron aqueous extract in mice with breast cancer

Abstract This study was to investigate whether high-intensity interval training (HIIT) and saffron aqueous extract (SAE) would provide a synergistic effect improve tumor volume reduction also modulate pro- anti-apoptotic protein expression in tissue of 4T1 breast cancer-bearing mice. Female mice following induction cancer through injection cell lines were randomly divided into four groups: (1) HIIT, (2) SAE, (3) HIIT+ (4) control. The significantly lower the HIIT+SAE groups than controls. level caspase-3 HIIT SAE higher control groups. Bax group showed Bcl-2 vs. both Finally, ratio Bax/Bcl-2 These findings indicate that combination interventions does not apoptotic tissue, while treatments may mediate pathway as evinced by elevated levels during progression